Unfortunately, like many larger breeds, Great Danes are susceptible to a type of bone cancer called osteosarcoma. It’s an extremely aggressive form of cancer that can quickly metastasize to the rest of the skeleton, and commonly the lungs. It first manifests within the dog’s bones before growing into a sizable tumor, making early detection difficult.
Causes of osteosarcoma remain unclear. Some veterinarians believe that bone injury may increase a dog’s risk of osteosarcoma, as injuries require more cellular turnover to heal a fracture or infection.