CBD in various cancer types and mechanism:

Figure 3. In vitro-in vivoanticancer mechanism of CBD in different types of cancer and the related effects on proliferation/apoptosis/gene expression/oxidative stress/tumor growth [76-199]

Kis, B., Ifrim, F. C., Buda, V., Avram, S., Pavel, I. Z., Antal, D., Paunescu, V., Dehelean, C. A., Ardelean, F., Diaconeasa, Z., Soica, C., & Danciu, C. (2019). Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer. International journal of molecular sciences, 20(23), 5905. https://doi.org/10.3390/ijms20235905

CBD anti-tumor effects single agent

1. Roberto D, Klotz LH, Venkateswaran V.  Cannabinoid WIN 55,212-2 induces cell cycle arrest and apoptosis, and inhibits proliferation, migration, invasion, and tumor growth in prostate cancer in a cannabinoid-receptor 2 dependent manner. Prostate. 2019 Feb;79(2):151-159. doi: 10.1002/pros.23720. Epub 2018 Sep 21.
2. Khan MI, Sobocińska AA, Brodaczewska KK, Zielniok K, Gajewska M, Kieda C, Czarnecka AM, Szczylik C. Involvement of the CB₂ cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma. BMC Cancer. 2018 May 23;18(1):583. doi: 10.1186/s12885-018-4496-1.
3. Fonseca BM, Correia-da-Silva G, Teixeira NA. Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. J Physiol Biochem. 2018 May;74(2):261-272. doi: 10.1007/s13105-018-0611-7. Epub 2018 Feb 13.
4. Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH. Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Anticancer Res. 2011 Nov;31(11):3799-807
5. Leelawat S, Leelawat K, Narong S, Matangkasombut O. The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Cancer Invest. 2010 May;28(4):357-63.
6. Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar AR, Shilo K, Carson WE 3rd, Ganju RK (2015) Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanism
7. Cioni C, Tassi M, Marotta G, Mugnaini C, Corelli F, Annunziata P. A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors. Cent Nerv Syst Agents Med Chem. 2019;19(3):206-214. doi: 10.2174/1871524919666190923154351. high TGF beta levels prevent checkpoint inhibitor action anti-PDL1
8. Dhital S, Stokes JV, Park N, Seo KS, Kaplan BL. Cannabidiol (CBD) induces functional Tregs in response to low-level T cell activation. Cell Immunol. 2017 Feb;312:25-34. doi: 10.1016/j.cellimm.2016.11.006. Epub 2016 Nov 9.

CBD in combination with chemotherapeutics

1. Fraguas-Sánchez AI, Fernández-Carballido A, Simancas-Herbada R, Martin-Sabroso C, Torres-Suárez AI. CBD loaded microparticles as a potential formulation to improve paclitaxel and doxorubicin-based chemotherapy in breast cancer. Int J Pharm. 2020 Jan 25;574:118916. doi: 10.1016/j.ijpharm.2019.118916. Epub 2019 Dec 4.
2. Ferro R, Adamska A, Lattanzio R, Mavrommati I, Edling CE, Arifin SA, Fyffe CA, Sala G, Sacchetto L, Chiorino G, De Laurenzi V, Piantelli M, Sansom OJ, Maffucci T, Falasca M. GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine. Oncogene. 2018 Dec;37(49):6368-6382. doi: 10.1038/s41388-018-0390-1. Epub 2018 Jul 30.
3. Donadelli M, Dando I, Zaniboni T, Costanzo C, Dalla Pozza E, Scupoli MT, Scarpa A, Zappavigna S, Marra M, Abbruzzese A, Bifulco M, Caraglia M, Palmieri M. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis. 2011 Apr 28;2:e152. doi: 10.1038/cddis.2011.36.

CBD prevents side effects from chemotherapy (neuropathy, nephrotoxicity, cardiotoxicity)

1. Deng L, Guindon J, Cornett BL, Makriyannis A, Mackie K, Hohmann AG. Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal. Biol Psychiatry. 2015 Mar 1;77(5):475-87. doi: 10.1016/j.biopsych.2014.04.009. Epub 2014 Apr 25.
2. Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther. 2009 Mar;328(3):708-14. doi: 10.1124/jpet.108.147181. Epub 2008 Dec 12.
3. Hao E, Mukhopadhyay P, Cao Z, Erdélyi K, Holovac E, Liaudet L, Lee WS, Haskó G, Mechoulam R, Pacher P. Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Mol Med. 2015 Jan 6;21:38-45. doi: 10.2119/molmed.2014.00261.

CBD Case Studies

1. Likar R¹, Koestenberger M¹, Stultschnig M², Nahler G Concomitant Treatment of Malignant Brain Tumours With CBD – A Case Series and Review of the Literature. Anticancer Res. 2019 Oct;39(10):5797-5801. doi: 10.21873/anticanres.13783.
2. Barrie, Allison M et al. “Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma.” Gynecologic oncology reports vol. 29 10-12. 17 May. 2019, doi:10.1016/j.gore.2019.05.004

Ovarian Cancer

1. Hennessy BT, Coleman RL, Markman M. Ovarian cancer. Lancet. 2009 Oct 17;374(9698):1371-82. doi: 10.1016/S0140-6736(09)61338-6. Epub 2009 Sep 28. PMID: 19793610.
2. Maurie Markman, James Hall, Daniel Spitz, Sheldon Weiner, Linda Carson, Linda Van Le, and Mark Baker Phase II Trial of Weekly Single-Agent Paclitaxel in Platinum/Paclitaxel-Refractory Ovarian Cancer

   Journal of Clinical Oncology 2002 20:9, 2365-2369

3. Daliah Tsoref, Stephen Welch, Susie Lau, James Biagi, Katia Tonkin, Lee Ann Martin, Susan Ellard, Prafull Ghatage, Laurie Elit, Helen J. Mackay, Ghassan Allo, Ming-Sound Tsao, Suzanne Kamel-Reid, Elizabeth A. Eisenhauer, Amit M. Oza, Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer, Gynecologic Oncology, Volume 135, Issue 2, 2014.