These Guidelines are Not for CBD in General: Pebble products are proprietary formulas specifically designed to assist with serious neurological conditions. Hemp-CBD is only one of the active plant-based ingredients. The following guidelines do not pertain to general CBD consumption.
Not for Distribution: This guideline is intended as an in-house reference to help healthcare professionals determine the most effective serving size of Pebble products for their clients.
Safety, Efficacy & Consistency: Pebble maintains protocols above the FDA’s supplements requirements by conducting two-rounds of Independent 3rd party testing for every batch and maintaining pharmaceutical variance standards. First, they test the individual ingredients before manufacturing. Second, a sample from every completed batch is tested by a separate third party lab. Every batch’s results can be reviewed via the “Track Your Batch” page.
Not Intended to Replace Prescription Medication: Pebble products are sold over-the-counter. They are not intended to replace prescribed medications. Consult with a physician before choosing to do so.
When & How to Use Pebble Products:
Liquid Caps: Most effective as a preventative, for long-term maintenance and symptom reduction (e.g. prevent most migraines from ever starting). Ingest 20-30 minutes before a meal and/or before bedtime. Effects begin to be felt in 30-45 minutes, provides systematic relief and builds cannabinoids in system over time. Most efficient product long-term, but takes longer (a few days, up to 3 weeks) for results to set-in.
Infused Oil: Most effective for immediate relief (e.g. migraine first coming on) or in emergency (e.g. to stop epileptic seizure or PTSD anxiety attack). Take sublingual. Enters the bloodstream in 90 seconds. Effects felt within 5-15 minutes, last 3+ hours. Also effective (but not most efficient) for long-term maintenance
Transitioning From a CBD-only Product: Begin with a 1:1 replacement (e.g. if taking 50mg of product X oil per day, simply swap out for 50mg of Pebble infused oil). In 3-5 days max, the client should notice substantive difference. Over time, many then reduce their overall intake (making it more cost effective), due to Pebble’s targeted formula.
Titration Rule-of-Thumb: The full titration rule of thumb is two (2) mg of CBD per pound of body weight, twice a day. For example: a 200 lb person could take 800 mg per day, before concerns about ‘side effects’ (see below). For all except the most extreme cases (e.g. Intractable Epilepsy) the most-effective dose will be a fraction of titration and of no concern.
Mild Nausea or Diarrhea, if Ingest More Than Full Titration (see above): Too much of any good thing is not good. Most clients find their effective dose is a fraction of full titration.
Mild Drowsiness: If a client takes more than their most-effective dose, the first indicator of the need to dial back is mild drowsiness that will be slept off in 4-6 hours. This fact can be used as a tool to help find an individual’s most effective dose or as a mild sedative (more details under “Dosing Recommendations”).
Pets: safe and effective for dogs, cats & other mammals, with same age & behavior-related symptoms as humans (e.g. inflammation, anxiety, hyperactivity). Dosing is the key factor. Using the infused oil, place a few drops on a treat or in food. One oil dropper holds 30 drops and contains 50 mg CBD. With full titration at two (2) mg CBD per pound of body weight, twice a day (e.g. 20 lb dog = 80 mg per day max), most pets need only a few (3-10) drops. If desired effect not seen in 15 minutes, repeat until desired effect or reach max titration. Signs of too much include vomiting, lethargy & diarrhea. If any of these occur, provide water and call your vet.
*Special Statement regarding Warfarin (Coumadin): Check INR lab testing within 3-5 days of initiating/changing Pebble serving size while on Warfarin – re-check INR levels in 1 week intervals until Pebble serving & physician prescribed Warafin dose are stable. High INR may cause bleeding or higher risk of stroke, low INR may increase risk of stroke or blood clots.
*Check with your physician before taking Pebble if you are currently using any of the following prescription medications: clopidogrel, phenytoin, amitriptyline, or sulfoylureas.
*Potential Prescription Drug Interactions with CBD: Clobazam (A first line treatment for Dravet Syndrome)
*Special Statement regarding other prescription medications: Always inform your prescribing physician if taking Pebble. Rare increases in liver function tests have been seen at high doses of CBD.